Antimicrobial Activities of Amine- and Guanidine-Functionalized Cholic Acid Derivatives

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Antimicrobial activities of amine- and guanidine-functionalized cholic acid derivatives.

Compounds in a series of cholic acid derivatives, designed to mimic the activities of polymyxin B and its derivatives, act as both potent antibiotics and effective permeabilizers of the outer membranes of gram-negative bacteria. Some of these compounds rival polymyxin B in antibacterial activity against gram-negative bacteria and are also very active against gram-positive organisms. Other compo...

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one-pot synthesis of tetrahydropyrimido[4,5-b]quinoline derivatives using sulfonic acid functionalized sba-15 and their antimicrobial activities

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1999

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.43.6.1347